Viruses and lymphocytes in rheumatoid arthritis. I. Studies on cultured rheumatoid lymphocytes.
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منابع مشابه
Viruses and lymphocytes in rheumatoid arthritis. I. Studies on cultured rheumatoid lymphocytes.
Synovial fluid lymphocytes from patients with rheumatoid arthritis have been examined for evidence of a productive infection with retroviruses by electron microscopy, labelling with 3H-uredine, growth in soft agar, and culturing in conditioned medium. No such viruses were detected. In addition, the synovial lymphocytes were activated before fusion and cocultivation with several cell lines which...
متن کاملStudies on synovial fluid lymphocytes in rheumatoid arthritis.
Rheumatoid arthritis (RA) is a systemic disease in which the major lesion is a chronic inflammation of the synovial membrane, with a characteristic though not pathognomonic histology. Rheumatoid activity in the synovial membrane may lead to the production of an increased amount of synovial fluid which in active cases is often richly cellular with polymorphs, monocyte-like cells, or lymphocytes ...
متن کاملViruses and lymphocytes in rheumatoid arthritis. II. Examination of lymphocytes and sera from patients with rheumatoid arthritis for evidence of retrovirus infection.
The possible involvement of retroviruses in the aetiology of rheumatoid arthritis (RA) was investigated. Retrovirus antigens were not expressed on rheumatoid synovial and peripheral blood lymphocytes as judged by membrane immunofluorescence, radioimmunoassay, and complement-mediated cytotoxicity. The specific antiretroviral (anti-RD-144 and anti-SSAV) sera used in this study were produced in ra...
متن کاملCells of the synovium in rheumatoid arthritis. T lymphocytes
Recent findings have substantiated the importance of T lymphocytes to the pathogenesis of rheumatoid arthritis (RA). Here, we review emerging data regarding genetic predisposition, spontaneous animal models of arthritis, and cell-cell interactions that implicate T cells as driving synovial inflammation and joint destruction. Information regarding the proinflammatory role of interleukin-17-produ...
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ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 1979
ISSN: 0003-4967
DOI: 10.1136/ard.38.6.507